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It kills any kind of cells regardless of the expression of c-Met protein, and the cytotoxicity of tivantinib is related to inhibit microtubule assembly ( Cabozantinib is a novel small-molecule multi-target tyrosine kinase inhibitor of c-Met, VEGFRs, RET, KIT, and AXL (Yakes et al., 2011)

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Swim latency, swim distance, time spent in the target quadrant, and number of quadrant crossings were recorded using a computerized video tracking system [2]